What does 'poke' refer to in the expression 'pig in a poke'. [1] Because some cases of microcephaly and its associated symptoms may be a result of amino acid deficiencies, treatment with amino acids in these cases has been shown to improve symptoms such as seizures and motor function delays. [1] Microcephaly serves as an important neurological indication or warning sign, but no uniformity exists in its definition.
[47], Microlissencephaly is microcephaly combined with lissencephaly (smooth brain surface due to absent sulci and gyri). [52] Due to their proximity to the bomb, the pregnant women's in utero children received a biologically significant radiation dose that was relatively high due to the massive neutron output of the lower explosive-yielding Little Boy. Pinheaded definition is - dull, stupid. Convulsions may also occur. How to use pinheaded in a sentence. Microcephaly is a feature common to several different genetic disorders arising from a deficiency in the cellular DNA damage response. A certain 'dwarf' of Punt (ancient Somalia) was given by the Chief clans as partial tribute to the last ruler of Ancient Egypt's Old Kingdom, Jenny Lee Snow and Elvira Snow, whose stage names were Pip and Zip, respectively, were sisters with microcephaly who acted in the 1932 film, This page was last edited on 17 October 2020, at 02:02. Microcephaly may be present at birth or it may develop in the first few years of life. Therefore, because the size of the brain is most often determined by the size of one's skull, the use of classifying, "microcephaly", in more modern literature, is today almost always implied when discussing cases wherein microcephaly manifests. [2] Many genetic syndromes can result in microcephaly, including chromosomal and single-gene conditions, though almost always in combination with other symptoms.

[52] Researchers studied 286 additional children who were in utero during the atomic bombings, and after a year they found these children had a higher incidence of microcephaly and mental retardation. See the full definition for pinheaded in the English Language Learners Dictionary, Thesaurus: All synonyms and antonyms for pinheaded. [3] External toxins to the embryo, such as alcohol during pregnancy or vertically transmitted infections, can also result in microcephaly. Microcephaly is a medical condition in which the brain does not develop properly, resulting in a shorter-than-normal head.


Accessed 18 Oct. 2020. Often, people with this disorder have an intellectual disability, poor motor function, poor speech, abnormal facial features, seizures and dwarfism. Learn how and when to remove this template message, Congenital disorders of amino acid metabolism, International Society for Infectious Diseases, Centers for Disease Control and Prevention, abnormal spindle-like microcephaly-associated (ASPM) gene, xeroderma pigmentosum complementation group A, "Facts about Microcephaly | Birth Defects | NCBDDD | CDC", "Molecular genetics of human primary microcephaly: an overview", "Cephalic Disorders Fact Sheet | National Institute of Neurological Disorders and Stroke", "Microcephaly with Spastic Quadriplegia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials", "Practice Parameter: Evaluation of the child with microcephaly (an evidence-based review)", "OMIM Entry - # 617520 - MICROCEPHALY 18, PRIMARY, AUTOSOMAL DOMINANT; MCPH18", "Microcephaly in infants and children: Etiology and evaluation", "Interim Guidelines for Pregnant Women During a Zika Virus Outbreak — United States, 2016", "Neuroimaging Findings of Organic Acidemias and Aminoacidopathies", "OMIM Entry - # 247200 - Miller-Dieker Lissencephaly Syndrome; MDLS", "Pediatric Abusive Head Trauma (Shaken Baby Syndrome)", "HIV Encephalopathy: pediatric case series description and insights from the clinic coalface", "Genetic disorders of thyroid metabolism and brain development", "Discussion: 'Microcephaly associated with congenital heart defect' by Barbu et al", "Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia", "Rare chromosomal deletions and duplications increase risk of schizophrenia", "DUF1220 domains, cognitive disease, and human brain evolution", "Sex-dependent association of common variants of microcephaly genes with brain structure", "Zika virus - Brazil: confirmed Archive Number: 20150519.3370768", "Zika Virus and Birth Defects — Reviewing the Evidence for Causality", "CDC Concludes Zika Causes Microcephaly and Other Birth Defects", "CDC issues interim travel guidance related to Zika virus for 14 Countries and Territories in Central and South America and the Caribbean", "CDC issues travel advisory for 14 countries with alarming viral outbreaks]", "Zika Virus Associated with Microcephaly", "Microcephaly - Definition of Microcephaly by Merriam-Webster", "WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells", "Study of Adolescents Exposed in Utero to the Atomic Bomb, Nagasaki, Japan", "Novel genetic loci underlying human intracranial volume identified through genome-wide association", "Genomic variants and variations in malformations of cortical development", "FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis", "Mutations in PNKP cause microcephaly, seizures and defects in DNA repair", "Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]", "Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size", "Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells", "Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice", Interview with Bill Griffith, Goblin Magazine 1995, https://en.wikipedia.org/w/index.php?title=Microcephaly&oldid=983921737, Short description is different from Wikidata, Articles needing additional references from February 2016, All articles needing additional references, Creative Commons Attribution-ShareAlike License, A baby with microcephaly (left) compared to a baby with a typical head size, Chromosomal (balanced rearrangements and ring chromosome).

[8] As the child grows older, the smallness of the skull becomes more obvious, although the entire body also is often underweight and dwarfed. Biologically, during conception the head fails to grow in time with the face – which continues to develop at a normal rate; this produces a person with a small… Pinhead definition is - the head of a pin. Occasional cases develop normal intelligence and grow normally (apart from persistently small head circumference). Hyperactivity and intellectual disability are common occurrences, although the degree of each varies. Send us feedback. How to use a word that (literally) drives some pe... Name that government! [59] In addition, viruses such as cytomegalovirus (CMV) or Zika have been shown to infect and kill the primary stem cell of the brain—the radial glial cell, resulting in the loss of future daughter neurons. [62] Individuals with the following DNA damage response disorders exhibit microcephaly: Nijmegen breakage syndrome, ATR-Seckel syndrome, MCPH1-dependent primary microcephaly disorder, xeroderma pigmentosum complementation group A deficiency, Fanconi anemia, ligase 4 deficiency syndrome and Bloom syndrome. For the genus of beetle, see, Condition in which the head is small due to an underdeveloped brain. Microcephaly is a medical condition in which the brain does not develop properly, resulting in a shorter-than-normal head.


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